Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas

  • Bioorg Med Chem Lett. 2011 Feb 15;21(4):1102-4. doi: 10.1016/j.bmcl.2010.12.130.
Hao Peng  1 ,  Yongju Liang ,  Le Chen ,  Liwu Fu ,  Haiqin Wang ,  Hongwu He
Affiliations
  • 1. Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, and College of Chemistry, Central China Normal University, Wuhan 430079, PR China.
PMID: 21273072 DOI: 10.1016/j.bmcl.2010.12.130
Abstract

The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various Cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC(50) 10.72 and 9.91 μM, respectively.