1215541-47-1
1215541-47-1
Chemical Structure
Cilostazol-d4
Synonym(s): OPC-13013-d4
- CAS No.: 1215541-47-1
- Formula:C20H23D4N5O2
- Molecular Weight:373.49
IUPAC Name: 6-(4-(1-(cyclohexyl-2,2,6,6-d4)-1H-tetrazol-5-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one
InChIKey: RRGUKTPIGVIEKM-KXGHAPEVSA-N
SMILES: O=C1NC2=CC=C(C=C2CC1)OCCCCC3=NN=NN3C4C([2H])([2H])CCCC4([2H])[2H]
Biological Activity: Cilostazol-d4 is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM[1][2].
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Cilostazol-d4 | Cilostazol-d4 is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. | |||||||||||||||||||||
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Cilostazol (Standard) | ≥98% | Cilostazol (Standard) is the analytical standard of Cilostazol. This product is intended for research and analytical applications. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. | ||||||||||||||||||||
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Cilostazol-d11 | Cilostazol-d11 is the deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. | |||||||||||||||||||||
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Cilostazol-d2 | Cilostazol-d2 (OPC 13013-d2) is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. | |||||||||||||||||||||
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Cilostazol-d6 | Cilostazol-d6 (OPC 13013-d6) is deuterium labeled Cilostazol. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. | |||||||||||||||||||||
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Cilostazol | 99.77% | Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Minami N, et al. Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo. Life Sci. 1997;61(25):PL 383-9. [Content Brief]
