3062796-70-4
Chemical Structure
XAN-5
- CAS No.: 3062796-70-4
- Formula:C29H28ClNO7S
- Molecular Weight:570.05
InChIKey: IKTJIOIYAJVBGG-ZJSKVYKZSA-N
SMILES: CCN(C1=CC2=[O+]C3=C(CCC/C3=C\C4=CC=CS4)C(C5=CC=CC=C5C(O)=O)=C2C=C1)CC.O=Cl(=O)([O-])=O
Biological Activity: XAN-5 is a mitochondrial DNA G-quadruplex (mtG4) ligand with a Kd of 3.8 μM. XAN-5 selectively binds and stabilizes mtG4 structures, disrupting mitochondrial gene transcription and DNA replication. XAN-5 triggers mitochondrial dysfunction, ROS overproduction, G0 phase arrest and caspase-dependent apoptosis. XAN-5 inhibits autophagy and induces immunogenic cell death. XAN-5 inhibits tumor growth in a mouse liver cancer model while enhancing tumor-infiltrating CD4+ and CD8+ T cells. XAN-5 targets two cancer resistance mechanisms simultaneously. XAN-5 can be used for the research of liver cancer[1].
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XAN-5 | XAN-5 is a mitochondrial DNA G-quadruplex (mtG4) ligand with a Kd of 3.8 μM. XAN-5 selectively binds and stabilizes mtG4 structures, disrupting mitochondrial gene transcription and DNA replication. XAN-5 triggers mitochondrial dysfunction, ROS overproduction, G0 phase arrest and caspase-dependent apoptosis. XAN-5 inhibits autophagy and induces immunogenic cell death. XAN-5 inhibits tumor growth in a mouse liver cancer model while enhancing tumor-infiltrating CD4+ and CD8+ T cells. XAN-5 targets two cancer resistance mechanisms simultaneously. XAN-5 can be used for the research of liver cancer. | |||||||||||||||||||||
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Keywords
