15180-02-6
Chemical Structure
Amfonelic acid
Synonym(s): WIN-25978
- CAS. Nr.: 15180-02-6
- Formula:C18H16N2O3
- Molecular Weight:308.33
IUPAC Name: 7-benzyl-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
InChIKey: WHHHJDGNBVQNAU-UHFFFAOYSA-N
SMILES: O=C(O)C1=CN(C2=NC(CC3=CC=CC=C3)=CC=C2C1=O)CC
Biological Activity: Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter[1].
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Amfonelic acid | Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter. | |||||||||||||||||||||
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Keywords
