1615763-33-1
Chemical Structure
Bicyclo-GABA
- CAS. Nr.: 1615763-33-1
- Formula:C7H11NO2
- Molecular Weight:141.17
InChIKey: YFGNHEYEOLSERH-KZLJYQGOSA-N
SMILES: N[C@]12[C@](C2)([H])[C@H](CC1)C(O)=O
Biological Activity: Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC50 of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α1β2γ2 GABAA receptors with an EC50 of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery[1].
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Bicyclo-GABA | Bicyclo-GABA is a selective betaine/GABA transporter 1 (BGT1) competitive, non-transported inhibitor with an IC50 of 590 nM. Bicyclo-GABA exhibits low micromolar agonistic activity at α1β2γ2 GABAA receptors with an EC50 of 5.1 μM. Bicyclo-GABA displays 129 times higher activity for BGT1 than GAT3. Bicyclo-GABA serves as a valuable tool compound for deciphering its elusive pharmacological role in the brain and periphery. | |||||||||||||||||||||
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Keywords
