1942922-78-2
Chemical Structure
HBK001
- CAS. Nr.: 1942922-78-2
- Formula:C30H38N10O3
- Molecular Weight:586.69
InChIKey: SIDICARXPRUZQI-HSZRJFAPSA-N
SMILES: CC#CCN1C2=C(N(C(N(C2=O)CCCN3CCN(C4=NC(C5=CC=CC=C5)=NO4)CC3)=O)C)N=C1N6C[C@@H](CCC6)N
Biological Activity: HBK001 is an orally active and selective dual GPR119 agonist and DPP-IV inhibitor. HBK001 triggers cAMP production, PKA activation, CREB phosphorylation, glucose-stimulated insulin secretion, plasma incretin elevation, β-cell proliferation, and β-cell function gene up-regulation. HBK001 reduces blood glucose, ameliorates hyperglycemia, improves glucose tolerance, and enhances islet morphology. HBK001 can be used for the research of type 2 diabetes mellitus[1][2].
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HBK001 | HBK001 is an orally active and selective dual GPR119 agonist and DPP-IV inhibitor. HBK001 triggers cAMP production, PKA activation, CREB phosphorylation, glucose-stimulated insulin secretion, plasma incretin elevation, β-cell proliferation, and β-cell function gene up-regulation. HBK001 reduces blood glucose, ameliorates hyperglycemia, improves glucose tolerance, and enhances islet morphology. HBK001 can be used for the research of type 2 diabetes mellitus. | |||||||||||||||||||||
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- [1]. Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020;188:112017. [Content Brief]
- [2]. Huan Y, et al. The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo. Sci Rep. 2017;7(1):4351. Published 2017 Jun 28. [Content Brief]
Keywords
