Kmt2d - lysine methyltransferase 2D Gene

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Predicted to be involved in several processes, including histone H3-K4 methylation; positive regulation of intracellular Estrogen receptor signaling pathway; and regulation of gene expression. Predicted to act upstream of or within in utero embryonic development and regulation of gene expression. Predicted to be part of MLL3/4 complex. Human ortholog(s) of this gene implicated in Kabuki syndrome and esophagus squamous cell carcinoma. Orthologous to human KMT2D (lysine methyltransferase 2D). [provided by Alliance of Genome Resources, Apr 2022]