Shroom2 - shroom family member 2 Gene

Also Known as Apxl; Shrm2; 4832440C16; C630003H05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110380

Summary

Enables actin filament binding activity; beta-catenin binding activity; and protein domain specific binding activity. Involved in cell migration and melanosome organization. Acts upstream of or within cell-cell junction maintenance and negative regulation of actin filament depolymerization. Located in several cellular components, including adherens junction; apical plasma membrane; and bicellular tight junction. Colocalizes with cortical actin Cytoskeleton. Is expressed in several structures, including blood vessel; central nervous system; epithelium; inner ear; and retina inner plexiform layer. Orthologous to human SHROOM2 (shroom family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Shroom2 Products (8)

mRNA Protein Name
NM_001290684.1 NP_001277613.1 protein Shroom2 isoform 2
NM_001290685.1 NP_001277614.1 protein Shroom2 isoform 3 precursor
NM_001290686.1 NP_001277615.1 protein Shroom2 isoform 4
NM_001290687.2 NP_001277616.1 protein Shroom2 isoform 4
NM_001359158.1 NP_001346087.1 protein Shroom2 isoform 4
NM_001359161.1 NP_001346090.1 protein Shroom2 isoform 4
NM_001359163.1 NP_001346092.1 protein Shroom2 isoform 4
NM_172441.3 NP_766029.2 protein Shroom2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables actin binding IDA
IDA: Inferred from direct assay
16684770 MGI
enables actin filament binding IDA
IDA: Inferred from direct assay
16684770 MGI
enables beta-catenin binding IDA
IDA: Inferred from direct assay
16684770 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17666436 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
17666436 MGI
Biological Process GO Annotation Evidence Verweise Source
NOT involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
16684770 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
16684770 MGI
NOT involved in cell morphogenesis IDA
IDA: Inferred from direct assay
16684770 MGI
acts upstream of or within cell-cell junction maintenance IDA
IDA: Inferred from direct assay
17666436 MGI
involved in melanosome organization IMP
IMP: Inferred from mutant phenotype
16987870 MGI
acts upstream of or within negative regulation of actin filament depolymerization IDA
IDA: Inferred from direct assay
17666436 MGI
Cellular Component GO Annotation Evidence Verweise Source
located in adherens junction IDA
IDA: Inferred from direct assay
16684770 MGI
located in apical junction complex IDA
IDA: Inferred from direct assay
17666436 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16684770 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
16684770 MGI
located in cell cortex IDA
IDA: Inferred from direct assay
17666436 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
17666436 MGI
colocalizes with cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
16684770 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17666436 MGI
located in cytoskeleton IDA
IDA: Inferred from direct assay
16684770 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
17666436 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16684770 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein Shroom2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12885 SHROOM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Shroom2 NCBI NCBI:357