MGAT4A - alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Gene

Also Known as GNT-IV; GnT-4a; GNT-IVA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11320

About MGAT4A

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:98,619,106-98,731,132 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues and 3 paralogues. Broad expression in small intestine (RPKM 18.3), colon (RPKM 13.7) and 24 other tissues.

Summary

This gene encodes a key Glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]

MGAT4A Products (2)

mRNA Protein Name
NM_001160154.2 NP_001153626.1 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2
NM_012214.3 NP_036346.1 alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
17006639 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in protein glycosylation IDA
IDA: Inferred from direct assay
17006639 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MGAT4A Protein Structure

Glyco_transf_54

Glyco_transf_54: N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region (81 - 380)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A

  • N-acetylglucosaminyltransferase IVa

Related Diseases

Diseases Alias
Choriocarcinoma

  • Chorioepithelioma
Congenital Disorder Of Glycosylation, Type Iia

  • CDG2A

  • Congenital Disorder Of Glycosylation Type Iia

  • Cdg Iia

  • Cdgiia

  • Congenital Disorder Of Glycosylation Type 2a

  • Alkuraya Syndrome

  • Mental Retardation, Growth Retardation, Prominent Columella, And Open Mouth

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii

  • Mgat2-Cdg

  • Cdg-Iia

  • Carbohydrate-Deficient Glycoprotein Syndrome, Type Ii, Formerly

  • Cdgs2, Formerly

  • Cdgs2

  • Cdg Syndrome Type Iia

  • Carbohydrate Deficient Glycoprotein Syndrome Type Iia

  • N-Acetylglucosaminyltransferase 2 Deficiency

  • Congenital Disorder Of Glycosylation 2a

  • Carbohydrate-Deficient Glycoprotein Syndrome Type Ii

  • Cdgs Type Ii

  • Carbohydrate-Deficient Glycoprotein Syndrome Type 2

  • Glycosylation, Congenital Disorder Of, Type Iia
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS08404 MGAT4A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-E70297 N-Acetylglucosaminyltransferase IVa / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MGAT4A VGNC VGNC:74714
Canis familiaris MGAT4A VGNC VGNC:54527
Mus musculus MGAT4A MGD MGI:2662992
Bos taurus MGAT4A VGNC VGNC:96699
Rattus norvegicus MGAT4A RGD RGD:1305650
Felis catus MGAT4A VGNC VGNC:68247