RNF212 - ring finger protein 212 Gene

Also Known as ZHP3; SPGF62

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 285498

About RNF212

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,056,251-1,113,710 (from NCBI)

This gene has 16 transcripts (splice variants), 98 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in ovary (RPKM 1.7), testis (RPKM 1.5) and 20 other tissues.

Summary

This gene encodes a RING finger protein that may function as a ubiquitin Ligase. The encoded protein may be involved in meiotic recombination. This gene is located within a linkage disequilibrium block and polymorphisms in this gene may influence recombination rates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]

RNF212 Products (5)

mRNA Protein Name
NM_001131034.4 NP_001124506.1 probable E3 SUMO-protein ligase RNF212 isoform a
NM_001193318.3 NP_001180247.1 probable E3 SUMO-protein ligase RNF212 isoform c
NM_001366918.1 NP_001353847.1 probable E3 SUMO-protein ligase RNF212 isoform d
NM_001366919.1 NP_001353848.1 probable E3 SUMO-protein ligase RNF212 isoform e
NM_194439.5 NP_919420.1 probable E3 SUMO-protein ligase RNF212 isoform b

RNF212 Protein Structure

zf-RING_5

zf-RING_5: zinc-RING finger domain (7 - 46)

  • 0
  • 100
  • 200
  • 297 a.a.
Protein Preferred Names Protein Names

probable E3 SUMO-protein ligase RNF212

  • probable E3 SUMO-protein transferase RNF212

Related Diseases

Diseases Alias
Spermatogenic Failure 62

  • SPGF62
Recombination Rate Quantitative Trait Locus 1

  • Recombination Rate Qtl 1

  • RRQTL1
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS12077 RNF212 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RNF212 MGD MGI:3645767
Canis familiaris RNF212 VGNC VGNC:45655
Macaca mulatta RNF212 VGNC VGNC:81558
Felis catus RNF212 VGNC VGNC:107442
Rattus norvegicus RNF212 RGD RGD:1588767