TM9SF4 - transmembrane 9 superfamily member 4 Gene

Also Known as dJ836N17.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9777

About TM9SF4

Cytogenetic location: 20q11.21 Genomic coordinates (GRCh38): 20:32,109,714-32,167,256 (from NCBI)

This gene has 7 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 20.7), brain (RPKM 16.4) and 25 other tissues.

Summary

Involved in several processes, including positive regulation of protein localization; regulation of intracellular pH; and vacuolar proton-transporting V-type ATPase complex assembly. Located in Golgi apparatus and early endosome. [provided by Alliance of Genome Resources, Apr 2022]

TM9SF4 Products (2)

mRNA	Protein	Name
NM_001363731.2	NP_001350660.1	transmembrane 9 superfamily member 4 isoform 2
NM_014742.4	NP_055557.2	transmembrane 9 superfamily member 4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25659576	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	25961573	GOA
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	19893578	GOA
involved in positive regulation of protein exit from endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	25999474	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	25999474	GOA
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	19893578	GOA
involved in response to hypoxia	IDA IDA: Inferred from direct assay	25961573	GOA
involved in vacuolar proton-transporting V-type ATPase complex assembly	IMP IMP: Inferred from mutant phenotype	25659576	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	25999474	GOA
located in early endosome	IDA IDA: Inferred from direct assay	19893578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TM9SF4 Protein Structure

EMP70

0
100
200
300
400
500
600
642 a.a.

Protein Preferred Names	Protein Names
transmembrane 9 superfamily member 4	dinucleotide oxidase disulfide thiol exchanger 3 superfamily member 4

TM9SF4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TM9SF4	Q92544	MTOR	Homo sapiens	P42345	Anti Bait CoIP	29125601

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14615	TM9SF4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TM9SF4	VGNC	VGNC:66230
Canis familiaris	TM9SF4	VGNC	VGNC:47417
Bos taurus	TM9SF4	VGNC	VGNC:35913
Rattus norvegicus	TM9SF4	RGD	RGD:1307768
Macaca mulatta	TM9SF4	VGNC	VGNC:79883
Mus musculus	TM9SF4	MGD	MGI:2139220
Others	TM9SF4	NCBI