Synthesis and antitumor activity of novel 2',3'-dideoxy-2',3'-diethanethionucleosides bearing 1,2,3-triazole residues

  • Bioorg Med Chem Lett. 2010 Jan 1;20(1):240-3. doi: 10.1016/j.bmcl.2009.10.127.
Jin-Lan Yu  1 ,  Qin-Pei Wu ,  Qing-Shan Zhang ,  Yan-Hong Liu ,  Yun-Zheng Li ,  Zi-Ming Zhou
Affiliations
  • 1. School of Chemical Engineering & Environment, Beijing Institute of Technology, Beijing 100081, China.
PMID: 19917528 DOI: 10.1016/j.bmcl.2009.10.127
Abstract

A series of novel 2',3'-dideoxy-2',3'-diethanethioribonucleosides and those modified with a triazole ring were prepared in excellent yields and their antitumor activity was evaluated. Nucleosides with a triazole ring, 16a-16c, showed significantly improved activity towards a broad range of tumor cell lines.