Kaempulchraols A-H, Diterpenoids from the Rhizomes of Kaempferia pulchra Collected in Myanmar

  • J Nat Prod. 2015 May 22;78(5):1113-8. doi: 10.1021/acs.jnatprod.5b00108.
Nwet Nwet Win  1  2 ,  Takuya Ito  1 ,  Simayijiang Aimaiti  1 ,  Hiroshi Imagawa  3 ,  Hla Ngwe  2 ,  Ikuro Abe  4 ,  Hiroyuki Morita  1
Affiliations
  • 1. †Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
  • 2. ‡Department of Chemistry, University of Yangon, Yangon 11041, Myanmar.
  • 3. §Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
  • 4. ⊥Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
PMID: 25919052 DOI: 10.1021/acs.jnatprod.5b00108
Abstract

Eight new Diterpenoids, kaempulchraols A-H (1-8), along with five known analogues were isolated from the CHCl3-soluble extract of rhizomes of Kaempferia pulchra of Myanmar. The structures of these compounds were elucidated using extensive spectroscopic techniques including X-ray diffraction analysis. All the isolates were tested for their antiproliferative activity against a panel of five human Cancer cell lines (A549, human lung cancer; HeLa, human cervix cancer; PANC-1 and PSN-1, human pancreatic cancer; MDA-MB-231, human breast Cancer) and TIG-3, normal human primary fibroblast cells. Kaempulchraol F (6) exhibited weak activity against the human pancreatic PSN-1 cell line with an IC50 value of 12.3 μM.