851220-34-3
851220-34-3
Chemical Structure
NI929
- CAS No.: 851220-34-3
- Formula:C12H19NO3S2
- Molecular Weight:289.41
InChIKey: HPLSBYWJIABNAJ-RYUDHWBXSA-N
SMILES: O=S(CC[C@H](N)[C@@H](S)CCC1=CC=CC=C1)(O)=O
Biological Activity: NI929 is a blood-brain barrier-permeable recombinant mouse aminopeptidase A (APA) inhibitor with a Ki value of 30 nM. NI929 is applicable to research on hypertension and Alzheimer's disease[1][2].
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NI929 | NI929 is a blood-brain barrier-permeable recombinant mouse aminopeptidase A (APA) inhibitor with a Ki value of 30 nM. NI929 is applicable to research on hypertension and Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Keck M, et al. NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension. Hypertension (Dallas, Tex. : 1979). 2019 Jun;73(6):1300-1307. [Content Brief]
- [2]. Loera-Valencia R, et al. Brain Renin-Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer's Disease. International journal of molecular sciences. 2021 Sep 20;22(18):10139. [Content Brief]
Keywords
