Cyfip1 - cytoplasmic FMR1 interacting protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 308666

Summary

Enables RNA 7-methylguanosine cap binding activity. Involved in several processes, including cellular response to Insulin stimulus; negative regulation of synaptic vesicle recycling; and positive regulation of cell projection organization. Located in several cellular components, including dendritic spine; distal axon; and filopodium tip. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in autism spectrum disorder and schizophrenia. Orthologous to human CYFIP1 (cytoplasmic FMR1 interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyfip1 Products (1)

mRNA Protein Name
NM_001107517.1 NP_001100987.1 cytoplasmic FMR1-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA 7-methylguanosine cap binding IDA
IDA: Inferred from direct assay
25453757 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
16260607 RGD
involved in negative regulation of synaptic vesicle recycling IMP
IMP: Inferred from mutant phenotype
26843638 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
16260607 RGD
involved in positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
16260607 RGD
involved in positive regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
16260607 RGD
involved in positive regulation of ruffle assembly IMP
IMP: Inferred from mutant phenotype
16260607 RGD
involved in regulation of myelination IMP
IMP: Inferred from mutant phenotype
31371763 RGD
involved in response to electrical stimulus IDA
IDA: Inferred from direct assay
25453757 RGD
Cellular Component GO Annotation Evidence References Source
located in axonal growth cone IDA
IDA: Inferred from direct assay
16260607 RGD
located in central region of growth cone IDA
IDA: Inferred from direct assay
16260607 RGD
located in dendritic growth cone IDA
IDA: Inferred from direct assay
16260607 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
24667445 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
24667445 RGD
located in filopodium tip IDA
IDA: Inferred from direct assay
16260607 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
16260607 RGD
located in peripheral region of growth cone IDA
IDA: Inferred from direct assay
16260607 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
26843638 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytoplasmic FMR1-interacting protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03430 CYFIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyfip1 NCBI NCBI:23191