Slco1b2 - solute carrier organic anion transporter family member 1B2 Gene

Also Known as Oatp4; OATP-4; rlst-1; Slco1b3; Slc21a10

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58978

Summary

Enables bile acid transmembrane transporter activity and oligopeptide transmembrane transporter activity. Involved in several processes, including bile acid and bile salt transport; response to glucocorticoid; and response to lipopolysaccharide. Located in basolateral plasma membrane. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in bilirubin metabolic disorder. Orthologous to several human genes including SLCO1B3 (solute carrier organic anion transporter family member 1B3). [provided by Alliance of Genome Resources, Apr 2022]

Slco1b2 Products (3)

mRNA Protein Name
NM_001270586.1 NP_001257515.1 solute carrier organic anion transporter family member 1B2 isoform 2
NM_001270587.1 NP_001257516.1 solute carrier organic anion transporter family member 1B2 isoform 3
NM_031650.3 NP_113838.1 solute carrier organic anion transporter family member 1B2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables bile acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
10500057 RGD
enables oligopeptide transmembrane transporter activity IDA
IDA: Inferred from direct assay
11677211 RGD
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
19129463 RGD
Biological Process GO Annotation Evidence References Source
involved in bile acid and bile salt transport IDA
IDA: Inferred from direct assay
10500057 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
15288467 RGD
involved in oligopeptide transport IDA
IDA: Inferred from direct assay
11677211 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
17916651 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
19118567 RGD
involved in response to lipid IEP
IEP: Inferred from expression pattern
19118567 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
18310902 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15840840 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19118567 RGD
Cellular Component GO Annotation Evidence References Source
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
15288467 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier organic anion transporter family member 1B2

  • liver-specific organic anion transporter 1

  • liver-specific transporter-1

  • organic anion transporting polypeptide 4

  • sodium-independent organic anion-transporting polypeptide 4

  • solute carrier family (organic anion transporter) member 10

  • solute carrier fa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13353 SLCO1B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13351 SLCO1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13352 SLCO1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown