Synthesis of 11,12-epoxydrim-8,12-en-11-ol, 11,12-diacetoxydrimane, and warburganal from (-)-sclareol

  • J Nat Prod. 1999 Nov;62(11):1488-91. doi: 10.1021/np990140q.
A F Barrero  1 ,  M Cortés ,  E A Manzaneda ,  E Cabrera ,  R Chahboun ,  M Lara ,  A R Rivas
Affiliations
  • 1. Departamento de Química Orgánica, Instituto de Biotecnología, Facultad de Ciencias, Universidad de Granada, Campus Fuentenueva s/n, 18071-Granada, Spain. [email protected]
PMID: 10579858 DOI: 10.1021/np990140q
Abstract

The first syntheses are reported for recently isolated drimanes 11, 12-epoxydrim-8,12-en-11-ol (2) and 11,12-diacetoxydrimane (3), from (-)-sclareol (1). Furthermore, two efficient new routes to the potent bioactive warburganal (4) starting also from 1 are described.