Withanolide-based steroids from the cultured soft coral Sinularia brassica

  • J Nat Prod. 2013 Oct 25;76(10):1902-8. doi: 10.1021/np400454q.
Chiung-Yao Huang  1 ,  Chih-Chuang Liaw ,  Bo-Wei Chen ,  Pei-Chin Chen ,  Jui-Hsin Su ,  Ping-Jyun Sung ,  Chang-Feng Dai ,  Michael Y Chiang ,  Jyh-Horng Sheu
Affiliations
  • 1. Department of Marine Biotechnology and Resources, National Sun Yat-sen University , Kaohsiung 804, Taiwan.
PMID: 24128077 DOI: 10.1021/np400454q
Abstract

Seven novel withanolides, sinubrasolides A-G (1-7), have been isolated from the cultured soft coral Sinularia brassica. The structures of the new metabolites were determined by extensive spectroscopic analyses, and the absolute configuration of 1 was established by X-ray crystallographic analysis. The cytotoxicities of compounds 1-7 against a limited panel of Cancer cell lines also were determined.