2489876-34-6
2489876-34-6
Chemical Structure
PROTAC BCR-ABL1 ligand 1
- CAS No.: 2489876-34-6
- Formula:C17H12F3N3O2
- Molecular Weight:347.29
IUPAC Name: 4-(6-((4-(trifluoromethoxy)phenyl)amino)pyrimidin-4-yl)phenol
InChIKey: UNNHUSXTCNMGSB-UHFFFAOYSA-N
SMILES: OC1=CC=C(C2=NC=NC(NC3=CC=C(OC(F)(F)F)C=C3)=C2)C=C1
Biological Activity: PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1[1].
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PROTAC BCR-ABL1 ligand 1 | 99.17% | PROTAC BCR-ABL1 ligand 1, compound GMB-475, is the ligand of PROTAC that allosterically targets BCR-ABL1 protein and recruits the E3 ligase Von Hippel-Lindau, resulting in ubiquitination and subsequent degradation of BCR-ABL1. | ||||||||||||||||||||
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References
Keywords
