2891620-68-9
Chemical Structure
CPD-1224
- CAS No.: 2891620-68-9
- Formula:C43H47ClN8O7S
- Molecular Weight:855.40
IUPAC Name: 5-(3-((4-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-methoxy-2-methylphenyl)piperidin-1-yl)methyl)azetidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIKey: YROLXKJYDUJWRK-UHFFFAOYSA-N
SMILES: ClC1=CN=C(NC2=C(OC)C=C(C3CCN(CC4CN(C5=CC=C6C(C(N(C7CCC(NC7=O)=O)C6=O)=O)=C5)C4)CC3)C(C)=C2)N=C1NC8=C(S(C(C)C)(=O)=O)C=CC=C8
Biological Activity: CPD-1224 is an orally effective ALK inhibitor, a derivative of an ALK inhibitor that connects to the cereblon ligand. CPD-1224 targets the EML4-ALK oncogenic fusion protein and degrades both ALK and the mutant forms L1196M/G1202R. CPD-1224 can slow down tumor growth[1].
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CPD-1224 | 99.83% | CPD-1224 is an orally effective ALK inhibitor, a derivative of an ALK inhibitor that connects to the cereblon ligand. CPD-1224 targets the EML4-ALK oncogenic fusion protein and degrades both ALK and the mutant forms L1196M/G1202R. CPD-1224 can slow down tumor growth. | ||||||||||||||||||||
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Keywords
