ZER1 - zyg-11 related cell cycle regulator Gene

Also Known as ZYG; C9orf60; ZYG11BL

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10444

About ZER1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,729,786-128,772,486 (from NCBI)

This gene has 4 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 20.9), testis (RPKM 20.5) and 25 other tissues.

Summary

This gene encodes a subunit of an E3 ubiquitin Ligase complex that may be involved in meiosis. The encoded protein contains three leucine-rich repeat motifs. [provided by RefSeq, Nov 2012]

ZER1 Products (7)

mRNA Protein Name
NM_001375954.1 NP_001362883.1 protein zer-1 homolog isoform 1
NM_001375955.1 NP_001362884.1 protein zer-1 homolog isoform 1
NM_001375956.1 NP_001362885.1 protein zer-1 homolog isoform 1
NM_001375957.1 NP_001362886.1 protein zer-1 homolog isoform 2
NM_001375958.1 NP_001362887.1 protein zer-1 homolog isoform 2
NM_001375959.1 NP_001362888.1 protein zer-1 homolog isoform 3
NM_006336.4 NP_006327.2 protein zer-1 homolog isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Biological Process GO Annotation Evidence Références Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
31273098 GOA
involved in protein quality control for misfolded or incompletely synthesized proteins IMP
IMP: Inferred from mutant phenotype
31273098 GOA
Cellular Component GO Annotation Evidence Références Source
part of Cul2-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17304241 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein zer-1 homolog

  • ZYG homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS16027 ZER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22362 Zer1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ZER1 MGD MGI:2442511
Macaca mulatta ZER1 VGNC VGNC:79906
Bos taurus ZER1 VGNC VGNC:37148
Canis familiaris ZER1 VGNC VGNC:48598
Felis catus ZER1 VGNC VGNC:67223
Rattus norvegicus ZER1 RGD RGD:1310284