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Nckap1l - NCK associated protein 1 like Gene

Also Known as Hem1; Hemp1; 4930568P13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 105855

Summary

Predicted to enable GTPase activator activity; TORC2 complex binding activity; and protein kinase activator activity. Involved in several processes, including lymphocyte homeostasis; negative regulation of cytokine production; and positive regulation of lymphocyte activation. Part of SCAR complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and musculature. Human ortholog(s) of this gene implicated in immunodeficiency 72. Orthologous to human NCKAP1L (NCK associated protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]

Nckap1l Products (1)

mRNA	Protein	Name
NM_153505.4	NP_705725.1	nck-associated protein 1-like

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Références	Source
involved in B cell homeostasis	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in T cell homeostasis	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	23424621	MGI
involved in erythrocyte homeostasis	IMP IMP: Inferred from mutant phenotype	23424621	MGI
involved in myeloid cell homeostasis	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of B cell differentiation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of CD8-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of cell adhesion mediated by integrin	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of erythrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of gamma-delta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of lymphocyte differentiation	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of neutrophil chemotaxis	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in positive regulation of phagocytosis, engulfment	IMP IMP: Inferred from mutant phenotype	19015308	MGI
involved in protein-containing complex assembly	IMP IMP: Inferred from mutant phenotype	19015308	MGI

Cellular Component GO Annotation	Evidence	Références	Source
part of SCAR complex	IMP IMP: Inferred from mutant phenotype	19015308	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
nck-associated protein 1-like	hematopoietic protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09083	NCKAP1L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nckap1l	NCBI	NCBI:3071