Erc1 - ELKS/RAB6-interacting/CAST family member 1 Gene

Also Known as ELKS; CAST2; Elks1; Rab6ip2; RAB6IP2A; RAB6IP2B; mKIAA1081; 4930404L01Rik; 5033405M01Rik; 9630025C19Rik; B430107L16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 111173

Summary

Enables small GTPase binding activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. A structural constituent of presynaptic active zone. Involved in synaptic vesicle priming. Acts upstream of or within retrograde transport, endosome to Golgi. Located in GABA-ergic synapse; cytoplasm; and glutamatergic synapse. Is expressed in several structures, including genitourinary system; gut gland; oral epithelium; retina; and telencephalon. Orthologous to human ERC1 (ELKS/RAB6-interacting/CAST family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Erc1 Products (2)

mRNA Protein Name
NM_053204.2 NP_444434.2 ELKS/Rab6-interacting/CAST family member 1 isoform 1
NM_178085.3 NP_835186.1 ELKS/Rab6-interacting/CAST family member 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11929610 MGI
enables small GTPase binding IDA
IDA: Inferred from direct assay
11929610 MGI
enables structural constituent of presynaptic active zone IDA
IDA: Inferred from direct assay
27537483 MGI
enables structural constituent of presynaptic active zone IEP
IEP: Inferred from expression pattern
27537483 MGI
enables structural constituent of presynaptic active zone IMP
IMP: Inferred from mutant phenotype
27537483 MGI
Biological Process GO Annotation Evidence Références Source
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
25209271 MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
25209271 MGI
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
25209271 MGI
involved in regulation of presynaptic cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
25209271 MGI
acts upstream of or within retrograde transport, endosome to Golgi IDA
IDA: Inferred from direct assay
11929610 MGI
involved in synaptic vesicle priming IDA
IDA: Inferred from direct assay
27253063 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
27253063 MGI
Cellular Component GO Annotation Evidence Références Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
25209271 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
25209271 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
11929610 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27253063 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27253063 MGI
located in podosome IDA
IDA: Inferred from direct assay
23525008 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
32521280 MGI
located in synapse IDA
IDA: Inferred from direct assay
23791195 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ELKS/Rab6-interacting/CAST family member 1

  • CAZ-associated structural protein 2

  • RAB6-interacting protein 2

  • Rab6 interacting protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS04476 ERC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erc1 NCBI NCBI:23085