Nek8 - NIMA (never in mitosis gene a)-related expressed kinase 8 Gene

Also Known as jck; b2b1449Clo; 4632401F23Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 140859

Summary

This gene encodes a NIMA-related kinase. Members of this serine/threonine protein kinase family are structurally-related to NIMA (never in Mitosis, gene A) which controls mitotic signaling in Aspergillus nidulans. [provided by RefSeq, Jul 2008]

Nek8 Products (1)

mRNA Protein Name
NM_080849.3 NP_543125.1 serine/threonine-protein kinase Nek8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
18235101 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Références Source
located in ciliary base IDA
IDA: Inferred from direct assay
20169535 MGI
located in ciliary inversin compartment IDA
IDA: Inferred from direct assay
20169535 MGI
located in cilium IDA
IDA: Inferred from direct assay
16267153 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase Nek8

  • NIMA-related expressed kinase 8

  • juvenile cystic kidney

  • never in mitosis A-related kinase 8

  • nimA-related protein kinase 8

Nek8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
Nek8 Q91ZR4 Invs Mus musculus O89019
Pull Down
22687244
Intra
Nek8 Q91ZR4 Invs Mus musculus O89019
Anti Tag CoIP
21565611
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09199 NEK8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21388 Nek8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27907 Nek8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nek8 NCBI NCBI:284086