Sptbn2 - spectrin beta, non-erythrocytic 2 Gene

Also Known as Spnb3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20743

Summary

A structural constituent of synapse. Involved in postsynapse organization. Acts upstream of or within adult behavior; cerebellar Purkinje cell layer morphogenesis; and synapse assembly. Located in apical plasma membrane; neuronal cell body; and paranodal junction. Is active in several cellular components, including glutamatergic synapse; parallel fiber to Purkinje cell synapse; and postsynaptic spectrin-associated Cytoskeleton. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and skin. Used to study spinocerebellar ataxia type 5. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 14 and spinocerebellar ataxia type 5. Orthologous to human SPTBN2 (spectrin beta, non-erythrocytic 2). [provided by Alliance of Genome Resources, Apr 2022]

Sptbn2 Products (1)

mRNA Protein Name
NM_021287.2 NP_067262.1 spectrin beta chain, non-erythrocytic 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables structural constituent of postsynapse IDA
IDA: Inferred from direct assay
28576936 MGI
enables structural constituent of postsynapse IMP
IMP: Inferred from mutant phenotype
28576936 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of or within adult behavior IMP
IMP: Inferred from mutant phenotype
20231455 MGI
acts upstream of or within cerebellar Purkinje cell layer morphogenesis IMP
IMP: Inferred from mutant phenotype
20231455 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
20231455 MGI
involved in postsynapse organization IDA
IDA: Inferred from direct assay
22090485 MGI
involved in postsynapse organization IMP
IMP: Inferred from mutant phenotype
22090485 MGI
involved in regulation of postsynaptic specialization assembly IDA
IDA: Inferred from direct assay
28576936 MGI
involved in regulation of postsynaptic specialization assembly IMP
IMP: Inferred from mutant phenotype
28576936 MGI
acts upstream of or within synapse assembly IMP
IMP: Inferred from mutant phenotype
20231455 MGI
Cellular Component GO Annotation Evidence Références Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21705333 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22090485 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22090485 MGI
located in neuronal cell body IDA
IDA: Inferred from direct assay
18796539 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
22090485 MGI
is active in parallel fiber to Purkinje cell synapse IMP
IMP: Inferred from mutant phenotype
22090485 MGI
is active in paranodal junction IDA
IDA: Inferred from direct assay
16687515 MGI
is active in postsynaptic spectrin-associated cytoskeleton IDA
IDA: Inferred from direct assay
28576936 MGI
is active in presynapse IDA
IDA: Inferred from direct assay
3531427 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

spectrin beta chain, non-erythrocytic 2

  • beta-spectrin 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS13733 SPTBN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sptbn2 NCBI NCBI:6712