Nexn - nexilin (F actin binding protein) Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 246172

Summary

Enables actin filament binding activity. Predicted to be involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; neuron development; and regulation of Cytoskeleton organization. Predicted to act upstream of or within response to bacterium. Located in Z disc and focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1CC and hypertrophic cardiomyopathy 20. Orthologous to human NEXN (nexilin F-actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Nexn Products (2)

mRNA Protein Name
NM_139230.2 NP_631976.1 nexilin isoform b
NM_139231.2 NP_631977.1 nexilin isoform s

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables actin filament binding IDA
IDA: Inferred from direct assay
9832551 RGD
Cellular Component GO Annotation Evidence Références Source
located in Z disc IDA
IDA: Inferred from direct assay
19881492 RGD
located in cell-substrate junction IDA
IDA: Inferred from direct assay
9832551 RGD
located in focal adhesion IDA
IDA: Inferred from direct assay
9832551 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nexilin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09232 NEXN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22253 Nexn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28775 Nexn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nexn NCBI NCBI:91624