Sh2d1b1 - SH2 domain containing 1B1 Gene

Also Known as Eat2; EAT-2; Eat2a; EAT-2A; Sh2d1b

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26904

Summary

Enables phosphotyrosine residue binding activity. Involved in leukocyte activation involved in immune response and positive regulation of natural killer cell mediated immunity. Acts upstream of or within several processes, including natural killer cell inhibitory signaling pathway; regulation of natural killer cell mediated cytotoxicity; and regulation of peptidyl-tyrosine phosphorylation. Orthologous to human SH2D1B (SH2 domain containing 1B). [provided by Alliance of Genome Resources, Apr 2022]

Sh2d1b1 Products (1)

mRNA Protein Name
NM_012009.5 NP_036139.3 SH2 domain-containing protein 1B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables phosphotyrosine residue binding IDA
IDA: Inferred from direct assay
9000139 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16127454 MGI
Biological Process GO Annotation Evidence Références Source
involved in leukocyte activation involved in immune response IDA
IDA: Inferred from direct assay
21149608 MGI
acts upstream of or within natural killer cell inhibitory signaling pathway IMP
IMP: Inferred from mutant phenotype
16127454 MGI
acts upstream of natural killer cell mediated cytotoxicity IGI
IGI: Inferred from genetic interaction
19648922 MGI
acts upstream of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16127454 MGI
acts upstream of or within negative regulation of natural killer cell mediated cytotoxicity IMP
IMP: Inferred from mutant phenotype
16127454 MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
16127454 MGI
acts upstream of or within negative regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
16127454 MGI
acts upstream of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
16425036 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
16127454 MGI
acts upstream of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
16127454 MGI
involved in positive regulation of innate immune response IDA
IDA: Inferred from direct assay
21149608 MGI
acts upstream of or within positive regulation of natural killer cell mediated cytotoxicity IGI
IGI: Inferred from genetic interaction
19648922 MGI
involved in positive regulation of natural killer cell mediated immunity IMP
IMP: Inferred from mutant phenotype
20962259 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
16425036 MGI
acts upstream of type II interferon production IMP
IMP: Inferred from mutant phenotype
16127454 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2 domain-containing protein 1B

  • EWS/FLI1 activated transcript 2

  • SH2 domain protein 1B1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS12822 SH2D1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown