Mkln1 - muskelin 1, intracellular mediator containing kelch motifs Gene

Also Known as A130067F06Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 27418

Summary

Enables identical protein binding activity. Involved in actin Cytoskeleton reorganization; cell-matrix adhesion; and regulation of cell shape. Located in several cellular components, including cell cortex; nucleoplasm; and ruffle. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ epithelium; and vibrissa. Orthologous to human MKLN1 (muskelin 1). [provided by Alliance of Genome Resources, Apr 2022]

Mkln1 Products (1)

mRNA	Protein	Name
NM_013791.2	NP_038819.1	muskelin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25579817	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18710924	MGI

Biological Process GO Annotation	Evidence	Références	Source
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	9724633	MGI
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	9724633	MGI
involved in neurotransmitter receptor transport postsynaptic membrane to endosome	IDA IDA: Inferred from direct assay	21482357	MGI
involved in neurotransmitter receptor transport postsynaptic membrane to endosome	IEP IEP: Inferred from expression pattern	21482357	MGI
involved in neurotransmitter receptor transport postsynaptic membrane to endosome	IMP IMP: Inferred from mutant phenotype	21482357	MGI
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	9724633	MGI
involved in vesicle-mediated transport in synapse	IDA IDA: Inferred from direct assay	21482357	MGI
involved in vesicle-mediated transport in synapse	IEP IEP: Inferred from expression pattern	21482357	MGI
involved in vesicle-mediated transport in synapse	IMP IMP: Inferred from mutant phenotype	21482357	MGI

Cellular Component GO Annotation	Evidence	Références	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	21482357	MGI
is active in GABA-ergic synapse	IEP IEP: Inferred from expression pattern	21482357	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	21482357	MGI
located in cell cortex	IDA IDA: Inferred from direct assay	9724633	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	21586270	MGI
located in cytosol	IDA IDA: Inferred from direct assay	9724633	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	18710924	MGI
is active in postsynaptic endosome membrane	IDA IDA: Inferred from direct assay	21482357	MGI
is active in postsynaptic specialization membrane of symmetric synapse	IDA IDA: Inferred from direct assay	21482357	MGI
is active in postsynaptic specialization membrane of symmetric synapse	IMP IMP: Inferred from mutant phenotype	21482357	MGI
located in ruffle	IDA IDA: Inferred from direct assay	9724633	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
muskelin

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS08472	MKLN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mkln1	NCBI	NCBI:4289