TREML4 - triggering receptor expressed on myeloid cells like 4 Gene

Also Known as TLT4; TLT-4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 285852

About TREML4

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,228,349-41,238,882 (from NCBI)

This gene has 3 transcripts (splice variants), 69 orthologues and 2 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable signaling receptor activity. Involved in positive regulation of Toll-like Receptor 7 signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface. Predicted to colocalize with endosome membrane and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TREML4 Products (1)

mRNA	Protein	Name
NM_198153.3	NP_937796.1	trem-like transcript 4 protein precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Références	Source
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	25848864	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TREML4 Protein Structure

V-set

0
100
200 a.a.

Protein Preferred Names	Protein Names
trem-like transcript 4 protein	TREM like transcript 4

Related Diseases

Diseases	Alias
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Nasu-Hakola Disease Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy Plosl Nhd Presenile Dementia With Bone Cysts Plo-Sl PLOSL1 Dementia, Prefrontal, With Bone Cysts Dementia, Progressive, With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease Progressive Dementia With Lipomembranous Polycystic Osteodysplasia Brain-Bone-Fat Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS15006	TREML4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TREML4	RGD	RGD:1587021
Mus musculus	TREML4	MGD	MGI:1923239