PIK3C2G - phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Gene

Also Known as PI3K-C2GAMMA; PI3K-C2-gamma

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5288

About PIK3C2G

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:18,242,961-18,726,817 (from NCBI)

This gene has 8 transcripts (splice variants), 183 orthologues and 9 paralogues. Biased expression in stomach (RPKM 3.1), skin (RPKM 2.0) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. This gene may play a role in several diseases, including type II diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

PIK3C2G Products (17)

mRNA	Protein	Name
XM_047429006.1	XP_047284962.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2
XM_011520697.3	XP_011518999.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X6
XM_017019471.2	XP_016874960.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
NM_001288772.2	NP_001275701.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 1
NM_004570.6	NP_004561.3	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 3
XM_011520701.3	XP_011519003.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X9
XR_931307.3
XM_017019478.3	XP_016874967.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X10
NM_001288774.2	NP_001275703.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform 2
XM_017019473.3	XP_016874962.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1
XM_047429009.1	XP_047284965.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X5
XM_047429010.1	XP_047284966.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X8
XM_047429005.1	XP_047284961.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X2
XM_017019475.2	XP_016874964.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X7
XM_017019479.2	XP_016874968.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X11
XM_047429008.1	XP_047284964.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X4
XM_047429007.1	XP_047284963.1	phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X3

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Références	Source
involved in modulation by host of viral process	IMP IMP: Inferred from mutant phenotype	19376974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PIK3C2G Protein Structure

PI3K_rbd

PI3K_C2

PI3Ka

PI3_PI4_kinase

PX

0
300
600
900
1200
1445 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	PTDINS-3-kinase C2 gamma phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma phosphoinositide-3-kinase, class 2, gamma polypeptide

Related Diseases

Diseases	Alias
Viral Labyrinthitis	Epidemic Vertigo Vestibular Neuronitis
Esophageal Atresia	Tracheoesophageal Fistula Congenital Atresia Of Esophagus Congenital Imperforate Esophagus Imperforate Esophagus Oesophageal Atresia Te Fistula Tef Tracheoesophageal Fistula With Or Without Esophageal Atresia
Spermatogenic Failure 17	SPGF17 Male Infertility Due To Oocyte Activation Failure Spermatogenic Failure, Type 17

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS10517	PIK3C2G Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10518	Pik3c2g Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10519	Pik3c2g Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PIK3C2G	VGNC	VGNC:75993
Felis catus	PIK3C2G	VGNC	VGNC:68852
Bos taurus	PIK3C2G	VGNC	VGNC:32887
Mus musculus	PIK3C2G	MGD	MGI:1203730
Canis familiaris	PIK3C2G	VGNC	VGNC:44553
Rattus norvegicus	PIK3C2G	RGD	RGD:620231
Others	PIK3C2G	NCBI