PRKX - protein kinase cAMP-dependent X-linked catalytic subunit Gene

Also Known as PKX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5613

About PRKX

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:3,604,340-3,713,649 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues and 5 paralogues. Broad expression in thyroid (RPKM 22.9), kidney (RPKM 7.3) and 20 other tissues.

Summary

This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]

PRKX Products (1)

mRNA	Protein	Name
NM_005044.5	NP_005035.1	cAMP-dependent protein kinase catalytic subunit PRKX

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables cAMP-dependent protein kinase activity	IDA IDA: Inferred from direct assay	10026146	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16491121	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in cell-substrate adhesion	IMP IMP: Inferred from mutant phenotype	16491121	GOA
involved in endothelial cell migration	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	21684272	GOA
involved in epithelial tube morphogenesis	IDA IDA: Inferred from direct assay	17980165	GOA
involved in kidney morphogenesis	IDA IDA: Inferred from direct assay	17980165	GOA
involved in myeloid cell differentiation	IDA IDA: Inferred from direct assay	9860982	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16491121	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	10026146	GOA
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	17980165	GOA
involved in regulation of cell migration	IDA IDA: Inferred from direct assay	17980165	GOA
involved in regulation of epithelial cell differentiation involved in kidney development	IDA IDA: Inferred from direct assay	17980165	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	10026146	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10026146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRKX Protein Structure

Pkinase

0
100
200
300
358 a.a.

Protein Preferred Names	Protein Names
cAMP-dependent protein kinase catalytic subunit PRKX	protein kinase PKX1

PRKX Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PRKX	P51817	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	PRKX	P51817	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	PRKX	P51817	PRKAR1A	Homo sapiens	P10644	Y2H	16491121
Intra	PRKX	P51817	PRKAR1A	Homo sapiens	P10644	Anti Tag CoIP	16491121
Intra	PRKX	P51817	GPKOW	Homo sapiens	Q92917	Anti Tag CoIP	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Anti Bait CoIP	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Protein Kinase Assay	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Y2H	16491121
Intra	PRKX	P51817	SMAD6	Homo sapiens	O43541	Anti Tag CoIP	16491121

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Asbestos-Related Lung Carcinoma
Breast Ductal Adenoma
Primary Pigmented Nodular Adrenocortical Disease	Ppnad Primary Pigmented Nodular Adrenal Dysplasia Pigmented Nodular Adrenocortical Disease, Primary, 2 Pigmented Nodular Adrenocortical Disease, Primary, 1
Acth-Independent Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenocortical Hyperplasia Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia Corticotropin-Independent Macronodular Adrenal Hyperplasia Cushing Syndrome Due To Macronodular Adrenal Hyperplasia AIMAH1 Aimah Massive Macronodular Adrenocortical Disease Mmad Primary Macronodular Adrenal Hyperplasia Cushing Syndrome, Adrenal, Due To Aimah Primary Bilateral Macronodular Adrenal Hyperplasia Acth-Independent Macronodular Adrenal Hyperplasia 1 Acth-Independent Cushing Syndrome Adrenal Cushing Syndrome Due To Aimah Acth-Independent Macronodular Adrenal Hyperplasia 2
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Breast Adenoma	Ademoma - Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS20329	Prkx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11159	PRKX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26837	Prkx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRKX	MGD	MGI:1309999
Rattus norvegicus	PRKX	RGD	RGD:1564076
Canis familiaris	PRKX	VGNC	VGNC:54833
Others	PRKX	NCBI