SEC14L1 - SEC14 like lipid binding 1 Gene

Also Known as SEC14L; PRELID4A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6397

About SEC14L1

Cytogenetic location: 17q25.2-q25.3 Genomic coordinates (GRCh38): 17:77,088,685-77,217,101 (from NCBI)

This gene has 23 transcripts (splice variants), 213 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 29.8), testis (RPKM 26.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86. [provided by RefSeq, Feb 2011]

SEC14L1 Products (7)

mRNA	Protein	Name
NM_001039573.3	NP_001034662.3	SEC14-like protein 1 isoform b
NM_001143998.2	NP_001137470.2	SEC14-like protein 1 isoform a
NM_001143999.2	NP_001137471.2	SEC14-like protein 1 isoform a
NM_001144001.2	NP_001137473.2	SEC14-like protein 1 isoform c
NM_001204408.2	NP_001191337.2	SEC14-like protein 1 isoform b
NM_001204410.2	NP_001191339.2	SEC14-like protein 1 isoform a
NM_003003.4	NP_002994.4	SEC14-like protein 1 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables RIG-I binding	IPI IPI: Inferred from physical interaction	23843640	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17092608	GOA
enables protein sequestering activity	IDA IDA: Inferred from direct assay	23843640	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in choline transport	IDA IDA: Inferred from direct assay	17092608	GOA
involved in negative regulation of RIG-I signaling pathway	IMP IMP: Inferred from mutant phenotype	23843640	GOA

Cellular Component GO Annotation	Evidence	Références	Source
colocalizes with Golgi apparatus	IDA IDA: Inferred from direct assay	17092608	GOA
is active in cytoplasm	IDA IDA: Inferred from direct assay	23843640	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17092608	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC14L1 Protein Structure

PRELI

CRAL_TRIO_N

CRAL_TRIO

0
200
400
600
715 a.a.

Protein Preferred Names	Protein Names
SEC14-like protein 1

SEC14L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	SEC14L1	Q92503	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	SEC14L1	Q92503	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Complement Component 7 Deficiency	C7 Deficiency C7D
Tylosis With Esophageal Cancer	Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome TOC Keratosis Palmaris Et Plantaris With Esophageal Cancer Bennion-Patterson Syndrome Howell-Evans Syndrome Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome Tylosis-Oesophageal Carcinoma Syndrome Palmoplantar Keratoderma With Esophageal Cancer Howel-Evans Syndrome Keratosis Palmoplantaris With Esophageal Cancer Tylosis - Oesophageal Carcinoma Howel-Evans' Syndrome
Phlyctenulosis	Phlyctenular Keratoconjunctivitis Strumous Ophthalmia
Amyotrophic Neuralgia	Neuralgic Amyotrophy Brachial Plexus Neuritis Neuralgic Shoulder Amyotrophy Acute Brachial Plexus Neuritis Immune Brachial Plexus Neuropathy Mononeuritis Multiplex With Brachial Predilection Parsonage-Turner Syndrome
Brachial Plexus Neuropathy	Brachial Plexopathy Brachial Plexus Neuropathies Brachial Plexus Disorder Bpn - [Brachial Plexus Neuropathy] Brachial Plexus Disease Neuropathic Plexus Brachialis Brachial Plexus Syndrome Brachial Plexus Irritation Brachial Plexus Lesion Brachial Plexus Pressure Compression Of Brachial Plexus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS12606	SEC14L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEC14L1	VGNC	VGNC:64961
Bos taurus	SEC14L1	VGNC	VGNC:34404
Mus musculus	SEC14L1	MGD	MGI:1921386
Macaca mulatta	SEC14L1	VGNC	VGNC:99226
Rattus norvegicus	SEC14L1	RGD	RGD:1563123
Canis familiaris	SEC14L1	VGNC	VGNC:45963
Others	SEC14L1	NCBI