SYDE1 - synapse defective Rho GTPase homolog 1 Gene

Also Known as 7h3; SYD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 85360

About SYDE1

Cytogenetic location: 19p13.12 Genomic coordinates (GRCh38): 19:15,107,401-15,114,974 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 9.3), placenta (RPKM 9.2) and 23 other tissues.

Summary

The protein encoded by this gene is a Rho GTPase-activating protein highly expressed in placenta. The encoded protein is involved in cytoskeletal remodeling and trophoblast cell migration. Decreased expression of this gene has been associated with intrauterine growth restriction (IUGR). [provided by RefSeq, Feb 2017]

SYDE1 Products (2)

mRNA Protein Name
NM_001300910.2 NP_001287839.1 rho GTPase-activating protein SYDE1 isoform 2
NM_033025.6 NP_149014.3 rho GTPase-activating protein SYDE1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
27917469 GOA
enables GTPase activator activity IMP
IMP: Inferred from mutant phenotype
27917469 GOA
enables GTPase regulator activity IDA
IDA: Inferred from direct assay
27917469 GOA
enables GTPase regulator activity IMP
IMP: Inferred from mutant phenotype
27917469 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within actin cytoskeleton organization IDA
IDA: Inferred from direct assay
27917469 GOA
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
27917469 GOA
acts upstream of or within cell migration IMP
IMP: Inferred from mutant phenotype
27917469 GOA
involved in positive regulation of trophoblast cell migration IMP
IMP: Inferred from mutant phenotype
27917469 GOA
involved in regulation of cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
27917469 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYDE1 Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (414 - 566)

  • 0
  • 200
  • 400
  • 600
  • 735 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein SYDE1

  • protein syd-1 homolog 1

Related Diseases

Diseases Alias
Autosomal Dominant Wolfram Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14073 SYDE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SYDE1 RGD RGD:1305857
Canis familiaris SYDE1 VGNC VGNC:47020
Bos taurus SYDE1 VGNC VGNC:35510
Mus musculus SYDE1 MGD MGI:1918959
Felis catus SYDE1 VGNC VGNC:80729