130636-43-0
130636-43-0
Chemical Structure
Nifekalant
Synonym(s): MS-551 free base
- CAS. Nr.: 130636-43-0
- Formula:C19H27N5O5
- Molecular Weight:405.45
IUPAC Name: 6-((2-((2-hydroxyethyl)(3-(4-nitrophenyl)propyl)amino)ethyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
InChIKey: OEBPANQZQGQPHF-UHFFFAOYSA-N
SMILES: O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O
Biological Activity: Nifekalant (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant can be used for refractory ventricular tachyarrhythmias research[1][2].
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Nifekalant | Nifekalant (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 μM. Nifekalant can be used for refractory ventricular tachyarrhythmias research. | |||||||||||||||||||||
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Nifekalant-d4 | Nifekalant-d4 is deuterium labeled Nifekalant. | |||||||||||||||||||||
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References
- [1]. Lü-Pei Du, et al. The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4771-7. [Content Brief]
- [2]. Ioannis N Pantazopoulos, et al. Nifekalant in the treatment of life-threatening ventricular tachyarrhythmias. World J Cardiol. 2011 Jun 26;3(6):169-76. [Content Brief]
Keywords
