Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5, 7-pentoxocanes and 1,2,4,5-tetroxanes

  • J Med Chem. 1999 Jul 15;42(14):2604-9. doi: 10.1021/jm990014j.
H S Kim  1 ,  Y Shibata ,  Y Wataya ,  K Tsuchiya ,  A Masuyama ,  M Nojima
Affiliations
  • 1. Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
PMID: 10411480 DOI: 10.1021/jm990014j
Abstract

A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.