Slc22a5 - solute carrier family 22 (organic cation transporter), member 5 Gene

Also Known as jvs; Lstpl; Octn2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 20520

Summary

Enables (R)-carnitine transmembrane transporter activity. Involved in (R)-carnitine transmembrane transport and transport across blood-brain barrier. Acts upstream of or within several processes, including adult heart development; carnitine metabolic process; and carnitine transport. Located in brush border membrane. Is expressed in several structures, including liver; metanephros; nasal cavity mucosa; spleen; and testis. Used to study systemic primary carnitine deficiency disease. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Orthologous to human SLC22A5 (solute carrier family 22 member 5). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a5 Products (3)

mRNA Protein Name
NM_001362711.1 NP_001349640.1 solute carrier family 22 member 5 isoform 2
NM_001362712.1 NP_001349641.1 solute carrier family 22 member 5 isoform 2
NM_011396.3 NP_035526.1 solute carrier family 22 member 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables (R)-carnitine transmembrane transporter activity IDA
IDA: Inferred from direct assay
20722056 MGI
enables (R)-carnitine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
14595704 MGI
enables carnitine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10454528 MGI
enables carnitine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
9634010 MGI
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: Inferred from direct assay
11010964 MGI
Biological Process GO Annotation Evidence References Source
involved in (R)-carnitine transmembrane transport IDA
IDA: Inferred from direct assay
10454528 MGI
involved in (R)-carnitine transmembrane transport IMP
IMP: Inferred from mutant phenotype
14595704 MGI
involved in (R)-carnitine transport IDA
IDA: Inferred from direct assay
20722056 MGI
acts upstream of or within adult heart development IMP
IMP: Inferred from mutant phenotype
9140816 MGI
acts upstream of or within carnitine metabolic process IMP
IMP: Inferred from mutant phenotype
1996978 MGI
acts upstream of or within carnitine transport IDA
IDA: Inferred from direct assay
11010964 MGI
acts upstream of or within carnitine transport IMP
IMP: Inferred from mutant phenotype
8155735 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
8670273 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
17027329 MGI
acts upstream of or within mitochondrion organization IMP
IMP: Inferred from mutant phenotype
7773507 MGI
acts upstream of or within quaternary ammonium group transport IDA
IDA: Inferred from direct assay
11010964 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
10100867 MGI
involved in response to tumor necrosis factor IDA
IDA: Inferred from direct assay
20722056 MGI
involved in response to type II interferon IDA
IDA: Inferred from direct assay
20722056 MGI
involved in transport across blood-brain barrier IMP
IMP: Inferred from mutant phenotype
14595704 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
20722056 MGI
located in brush border membrane IDA
IDA: Inferred from direct assay
15523054 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 22 member 5

  • high-affinity sodium-dependent carnitine cotransporter

  • juvenile visceral steatosis

  • organic cation/carnitine transporter 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13077 SLC22A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20645 Slc22a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27155 Slc22a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a5 NCBI NCBI:6584