Erc2 - ELKS/RAB6-interacting/CAST family member 2 Gene

Also Known as CAST; Cmbp

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 259269

Summary

Enables PDZ domain binding activity. Involved in synapse organization. Located in several cellular components, including distal axon; postsynaptic density; and presynaptic membrane. Part of protein-containing complex. Is active in presynaptic active zone cytoplasmic component. Orthologous to human ERC2 (ELKS/RAB6-interacting/CAST family member 2). [provided by Alliance of Genome Resources, Apr 2022]

Erc2 Products (2)

mRNA Protein Name
NM_001401498.1 NP_001388427.1 ERC protein 2 isoform 1
NM_170787.3 NP_740768.1 ERC protein 2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
12163476 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12163476 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
12163476 RGD
Biological Process GO Annotation Evidence References Source
involved in synapse organization IEP
IEP: Inferred from expression pattern
12163476 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi-associated vesicle IDA
IDA: Inferred from direct assay
22875941 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12163476 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12163476 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
22875941 RGD
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
12391317 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
12163476 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12163476 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
12163476 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ERC protein 2

  • CAST1

  • CAZ-associated structural protein 1

  • cytomatrix protein p110

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04477 ERC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Erc2 NCBI NCBI:26059