Hes2 - hes family bHLH transcription factor 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29567

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human HES2 (hes family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Hes2 Products (1)

mRNA Protein Name
NM_019236.1 NP_062109.1 transcription factor HES-2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8354270 RGD
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
8354270 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: Inferred from mutant phenotype
8354270 RGD
enables double-stranded DNA binding IDA
IDA: Inferred from direct assay
8354270 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8354270 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8354270 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transcription factor HES-2

  • hairy and enhancer of split 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-144501 D18 98.79% Unkown
HY-144497 HE-S2 / Unkown
HY-RS06135 HES2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20751 Hes2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27263 Hes2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hes2 NCBI NCBI:54626