RT1-Bb - RT1 class II, locus Bb Gene

Also Known as Bb; RT1.B

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 309622

Summary

Predicted to enable several functions, including peptide antigen binding activity; protein antigen binding activity; and toxic substance binding activity. Involved in cellular response to organic cyclic compound; defense response to fungus; and negative regulation of T cell proliferation. Located in cell surface. Used to study uveitis. Biomarker of pneumocystosis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); Bacterial infectious disease (multiple); hematologic Cancer (multiple); and liver disease (multiple). Orthologous to several human genes including HLA-DQB2 (major histocompatibility complex, class II, DQ beta 2). [provided by Alliance of Genome Resources, Apr 2022]

RT1-Bb Products (1)

mRNA Protein Name
NM_001004084.3 NP_001004084.1 rano class II histocompatibility antigen, B-1 beta chain precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
2465490 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
20377877 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
12034349 RGD
involved in cellular response to morphine IEP
IEP: Inferred from expression pattern
14742686 RGD
involved in defense response to fungus IEP
IEP: Inferred from expression pattern
20377877 RGD
involved in negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
9834080 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12034349 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rano class II histocompatibility antigen, B-1 beta chain

  • MHC class II antigen B beta chain

  • RT1 class II histocompatibility antigen, B-1 beta chain

  • RT1.B-beta(1)

  • RT1.Bbeta 1