95669-35-5
Chemical Structure
Wy 27127
- CAS No.: 95669-35-5
- Formula:C17H27N3O4S2
- Molecular Weight:401.54
InChIKey: VSQCTWPNMPWYSD-WBVHZDCISA-N
SMILES: CS(NCCN([C@H]1C[C@@]2([H])C3=CC=CC=C3CCN2CC1)S(C)(=O)=O)(=O)=O
Biological Activity: Wy 27127 is a potent and selective α2-adrenergic receptor antagonist. Wy 27127 competitively blocks α2-adrenergic receptors, interrupts the negative feedback loop of sympathetic nerve endings, enhances stimulus-evoked norepinephrine release, and blocks agonist-induced inhibition of vas deferens contraction. Wy 27127 shows weak antagonistic effects on α1 receptors, and exhibits no significant antagonistic activity against 5-hydroxytryptamine, muscarinic, presynaptic dopamine, histamine or β1-adrenergic receptors in vitro. Wy 27127 blocks saphenous vein contraction mediated by postsynaptic α2-adrenergic receptor agonists. Wy 27127 is applicable to studies related to sympathetic neurotransmission and vascular adrenergic responses[1][2].
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Wy 27127 | Wy 27127 is a potent and selective α2-adrenergic receptor antagonist. Wy 27127 competitively blocks α2-adrenergic receptors, interrupts the negative feedback loop of sympathetic nerve endings, enhances stimulus-evoked norepinephrine release, and blocks agonist-induced inhibition of vas deferens contraction. Wy 27127 shows weak antagonistic effects on α1 receptors, and exhibits no significant antagonistic activity against 5-hydroxytryptamine, muscarinic, presynaptic dopamine, histamine or β1-adrenergic receptors in vitro. Wy 27127 blocks saphenous vein contraction mediated by postsynaptic α2-adrenergic receptor agonists. Wy 27127 is applicable to studies related to sympathetic neurotransmission and vascular adrenergic responses. | |||||||||||||||||||||
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- [1]. Bill SJ et al. Some pharmacological properties of Wy 27127 a more selective alpha 2:alpha 1-adrenoceptor antagonist than idazoxan in vitro. Naunyn Schmiedebergs Arch Pharmacol. 1986 Dec;334(4):418-22. [Content Brief]
- [2]. Rhodes KF, et al. The effects of some alpha-adrenoceptor antagonists on the responses of the canine saphenous vein to B-HT 933, UK-14304 and methoxamine. Naunyn-Schmiedeberg's archives of pharmacology. 1987 Mar;335(3):261-8. [Content Brief]
Keywords
