Cdkn1c - cyclin-dependent kinase inhibitor 1C (P57) Gene

Also Known as CDKI; Kip2; p57Kip2; p57(kip2)

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12577

Summary

Predicted to enable protein kinase inhibitor activity. Involved in negative regulation of phosphorylation. Acts upstream of or within several processes, including animal organ development; genetic imprinting; and regulation of exit from Mitosis. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study Beckwith-Wiedemann syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Apr 2022]

Cdkn1c Products (20)

mRNA Protein Name
NM_001161624.2 NP_001155096.1 cyclin-dependent kinase inhibitor 1C isoform 1
NM_001354981.2 NP_001341910.1 cyclin-dependent kinase inhibitor 1C isoform 2
NM_001412230.1 NP_001399159.1 cyclin-dependent kinase inhibitor 1C isoform 3
NM_001412231.1 NP_001399160.1 cyclin-dependent kinase inhibitor 1C isoform 3
NM_001412232.1 NP_001399161.1 cyclin-dependent kinase inhibitor 1C isoform 1
NM_001412233.1 NP_001399162.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412234.1 NP_001399163.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412235.1 NP_001399164.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412236.1 NP_001399165.1 cyclin-dependent kinase inhibitor 1C isoform 4
NM_001412237.1 NP_001399166.1 cyclin-dependent kinase inhibitor 1C isoform 2
NM_001412238.1 NP_001399167.1 cyclin-dependent kinase inhibitor 1C isoform 2
NM_001412239.1 NP_001399168.1 cyclin-dependent kinase inhibitor 1C isoform 5
NM_001412240.1 NP_001399169.1 cyclin-dependent kinase inhibitor 1C isoform 6
NM_001412241.1 NP_001399170.1 cyclin-dependent kinase inhibitor 1C isoform 6
NM_001412242.1 NP_001399171.1 cyclin-dependent kinase inhibitor 1C isoform 6
NM_001412243.1 NP_001399172.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_001412244.1 NP_001399173.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_001412245.1 NP_001399174.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_001412246.1 NP_001399175.1 cyclin-dependent kinase inhibitor 1C isoform 7
NM_009876.5 NP_034006.3 cyclin-dependent kinase inhibitor 1C isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
14671317 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within adrenal gland development IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within digestive system development IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within embryonic placenta morphogenesis IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within genomic imprinting IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within myeloid cell differentiation IGI
IGI: Inferred from genetic interaction
15889154 MGI
involved in negative regulation of phosphorylation IDA
IDA: Inferred from direct assay
19170105 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
14671317 MGI
acts upstream of or within neuron maturation IMP
IMP: Inferred from mutant phenotype
14671317 MGI
acts upstream of or within placenta development IGI
IGI: Inferred from genetic interaction
9784491 MGI
acts upstream of or within placenta development IMP
IMP: Inferred from mutant phenotype
21729874 MGI
acts upstream of or within regulation of exit from mitosis IGI
IGI: Inferred from genetic interaction
9784491 MGI
acts upstream of or within regulation of lens fiber cell differentiation IGI
IGI: Inferred from genetic interaction
9784491 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
19276117 MGI
acts upstream of or within uterus development IMP
IMP: Inferred from mutant phenotype
19276117 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11737597 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cyclin-dependent kinase inhibitor 1C

  • cyclin-dependent kinase inhibitor p57

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02413 CDKN1C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20537 Cdkn1c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27046 Cdkn1c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdkn1c NCBI NCBI:1028