Adarb1 - adenosine deaminase, RNA-specific, B1 Gene

Also Known as Red1; Adar2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25367

Summary

This gene encodes a double-stranded-RNA-specific Adenosine Deaminase that is involved in editing pre-mRNAs by site-specific conversion of adenosine (A) to inosine (I). Substrates for this enzyme include ionotropic glutamate receptors (GluR2-6) and serotonin receptor (5HT2C). Studies in rodents have shown that this protein can modify its own pre-mRNA by A->I editing to create a novel acceptor splice site, alternative splicing to which results in down regulation of its protein expression. Additional splicing events result in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Adarb1 Products (4)

mRNA Protein Name
NM_001111055.1 NP_001104525.1 double-stranded RNA-specific editase 1 isoform 2
NM_001111056.1 NP_001104526.1 double-stranded RNA-specific editase 1 isoform 3
NM_001111057.1 NP_001104527.1 double-stranded RNA-specific editase 1 isoform 4
NM_012894.2 NP_037026.2 double-stranded RNA-specific editase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA binding IDA
IDA: Inferred from direct assay
10836790 RGD
enables double-stranded RNA adenosine deaminase activity IDA
IDA: Inferred from direct assay
8559253 RGD
enables double-stranded RNA binding IDA
IDA: Inferred from direct assay
16472753 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
16682559 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
23275536 RGD
Biological Process GO Annotation Evidence References Source
involved in adenosine to inosine editing IDA
IDA: Inferred from direct assay
8559253 RGD
involved in base conversion or substitution editing IDA
IDA: Inferred from direct assay
10836790 RGD
involved in mRNA modification IDA
IDA: Inferred from direct assay
14660658 RGD
involved in positive regulation of mRNA processing IDA
IDA: Inferred from direct assay
10331393 RGD
Cellular Component GO Annotation Evidence References Source
located in nucleoplasm IDA
IDA: Inferred from direct assay
14612560 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double-stranded RNA-specific editase 1

  • RNA editing deaminase of glutamate receptors

  • RNA-editing deaminase 1

  • RNA-editing enzyme 1

  • double stranded RNA specific deaminase RED1

  • dsRNA adenosine deaminase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00318 ADARB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adarb1 NCBI NCBI:104