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Cln8 - CLN8 transmembrane ER and ERGIC protein Gene

Also Known as mnd; Tlcd6

Species: Mus musculus

Gene Type: protein coding

Gene ID: 26889

Summary

Predicted to enable ceramide binding activity. Acts upstream of or within several processes, including adult walking behavior; glutamate reuptake; and neurofilament Cytoskeleton organization. Located in endoplasmic reticulum. Is expressed in several structures, including adrenal gland; gonad; hemolymphoid system gland; nervous system; and retina. Used to study neuronal ceroid lipofuscinosis 8. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 8 and neuronal ceroid lipofuscinosis 8 northern epilepsy variant. Orthologous to human CLN8 (CLN8 transmembrane ER and ERGIC protein). [provided by Alliance of Genome Resources, Apr 2022]

Cln8 Products (1)

mRNA	Protein	Name
NM_012000.3	NP_036130.1	protein CLN8

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19941651	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within adult locomotory behavior	IMP IMP: Inferred from mutant phenotype	12020865	MGI
acts upstream of or within adult walking behavior	IMP IMP: Inferred from mutant phenotype	2061715	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	15565184	MGI
acts upstream of or within associative learning	IMP IMP: Inferred from mutant phenotype	15885820	MGI
acts upstream of or within glutamate reuptake	IMP IMP: Inferred from mutant phenotype	8095977	MGI
acts upstream of or within lysosome organization	IMP IMP: Inferred from mutant phenotype	7613514	MGI
acts upstream of or within macromolecule catabolic process	IMP IMP: Inferred from mutant phenotype	15647513	MGI
acts upstream of or within mitochondrial membrane organization	IMP IMP: Inferred from mutant phenotype	9059519	MGI
acts upstream of or within musculoskeletal movement	IMP IMP: Inferred from mutant phenotype	2061715	MGI
acts upstream of or within negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15565184	MGI
acts upstream of or within negative regulation of transferase activity	IMP IMP: Inferred from mutant phenotype	8873145	MGI
acts upstream of or within neurofilament cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	2061715	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	9918704	MGI
acts upstream of or within neuromuscular process controlling posture	IMP IMP: Inferred from mutant phenotype	2061715	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15565184	MGI
acts upstream of or within phospholipid metabolic process	IMP IMP: Inferred from mutant phenotype	9245501	MGI
acts upstream of or within photoreceptor cell maintenance	IMP IMP: Inferred from mutant phenotype	9151333	MGI
acts upstream of or within protein catabolic process	IMP IMP: Inferred from mutant phenotype	8389815	MGI
acts upstream of or within protein metabolic process	IMP IMP: Inferred from mutant phenotype	1658691	MGI
acts upstream of or within regulation of cell size	IMP IMP: Inferred from mutant phenotype	15565184	MGI
acts upstream of or within retina development in camera-type eye	IMP IMP: Inferred from mutant phenotype	15565184	MGI
acts upstream of retinal rod cell apoptotic process	IMP IMP: Inferred from mutant phenotype	15565184	MGI
acts upstream of or within social behavior	IMP IMP: Inferred from mutant phenotype	12020865	MGI
acts upstream of or within somatic motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	21052544	MGI
acts upstream of or within spinal cord motor neuron differentiation	IMP IMP: Inferred from mutant phenotype	2061715	MGI
acts upstream of or within visual perception	IMP IMP: Inferred from mutant phenotype	7668363	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19941651	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
protein CLN8	ceroid-lipofuscinosis, neuronal 8 motor neuron degeneration

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02825	CLN8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cln8	NCBI	NCBI:2055