HES2 - hes family bHLH transcription factor 2 Gene

Also Known as bHLHb40

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54626

About HES2

Cytogenetic location: 1p36.31 Genomic coordinates (GRCh38): 1:6,415,232-6,419,919 (from NCBI)

This gene has 6 transcripts (splice variants), 236 orthologues and 12 paralogues. Biased expression in skin (RPKM 5.8), esophagus (RPKM 4.3) and 7 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in anterior/posterior pattern specification; regulation of neurogenesis; and regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HES2 Products (1)

mRNA Protein Name
NM_019089.5 NP_061962.2 transcription factor HES-2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HES2 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (15 - 70)

Hairy_orange

Hairy_orange: Hairy Orange (84 - 124)

  • 0
  • 100
  • 173 a.a.
Protein Preferred Names Protein Names

transcription factor HES-2

  • class B basic helix-loop-helix protein 40

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-144501 D18 98.79% Unkown
HY-144497 HE-S2 / Unkown
HY-RS06135 HES2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20751 Hes2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27263 Hes2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HES2 VGNC VGNC:29819
Felis catus HES2 VGNC VGNC:107551
Macaca mulatta HES2 VGNC VGNC:73174
Mus musculus HES2 MGD MGI:1098624
Rattus norvegicus HES2 RGD RGD:62082
Canis familiaris HES2 VGNC VGNC:41665