KLRC4 - killer cell lectin like receptor C4 Gene

Also Known as NKG2F; NKG2-F

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8302

About KLRC4

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,407,384-10,409,757 (from NCBI)

This gene has 1 transcript (splice variant), 368 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 6.6), lymph node (RPKM 3.0) and 17 other tissues.

Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. This gene is a member of the NKG2 group of genes that are expressed primarily in natural killer (NK) cells. These family members encode transmembrane proteins that are characterized by a type II membrane orientation (have an extracellular C-terminus) and the presence of a C-type lectin domain. This family member is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. Read-through transcription exists between this gene and the downstream KLRK1 (killer cell lectin-like receptor subfamily K, member 1) family member. [provided by RefSeq, Dec 2010]

KLRC4 Products (1)

mRNA Protein Name
NM_013431.2 NP_038459.1 NKG2-F type II integral membrane protein
Protein Preferred Names Protein Names

NKG2-F type II integral membrane protein

  • NK cell receptor F

Related Diseases

Diseases Alias
Behcet Syndrome

  • Behcet Disease

  • Behcet'S Syndrome

  • Behcet'S Disease

  • Behçet Disease

  • Bd

  • Adamantiades-Behcet Disease

  • Triple Symptom Complex

  • Behçet'S Disease

  • Behet'S Syndrome

  • Bd Syndrome

  • Behçet Syndrome

  • Behçet'S Syndrome

  • Behcet Triple Symptom Complex

  • Malignant Aphthosis

  • Old Silk Route Disease

  • Adamantiades-Behçet Disease
Immunodeficiency 31a

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Stat1 Deficiency

  • IMD31A

  • Immunodeficiency 31a, Mycobacteriosis, Autosomal Dominant

  • Stat1 Deficiency, Autosomal Dominant

  • Mendelian Susceptibility To Mycobacterial Diseases Due To Partial Signal Transducer And Activator Of Transcription 1 Deficiency

  • Msmd Due To Partial Signal Transducer And Activator Of Transcription 1 Deficiency

  • Msmd Due To Partial Stat1 Deficiency

  • Autosomal Dominant Immunodeficiency 31a, Mycobacteriosis

  • Immunodeficiency, Type 31a, Mycobacteriosis, Autosomal Dominant
Immunodeficiency 31c

  • IMD31C

  • Candidiasis, Familial, 7

  • Candf7

  • Candidiasis, Familial Chronic Mucocutaneous, Autosomal Dominant

  • Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome

  • Autoimmune Enteropathy And Endocrinopathy - Susceptibility To Chronic Infections Syndrome

  • Immunodeficiency 31c, Chronic Mucocutaneous Candidiasis, Autosomal Dominant

  • Autosomal Dominant Chronic Mucocutaneous Familial Candidiasis

  • Autosomal Dominant Immunodeficiency 31c

  • Familial Candidiasis 7

  • Chronic Mucocutaneous Candidiasis 7

  • Immunodeficiency 31c, Autosomal Dominant

  • Immunodeficiency, Type 31c, Autosomal Dominant
Aphthous Stomatitis

  • Oral Ulcer

  • Canker Sore

  • Aphtha

  • Aphthous Ulceration

  • Oral Aphthae

  • Oral Aphthous Ulcer

  • Canker Sores

  • Stomatitis, Aphthous

  • Minor Oral Aphthous Ulceration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07394 KLRC4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown