PLEK2 - pleckstrin 2 Gene
Species: Homo sapiens
About PLEK2
This gene has 6 transcripts (splice variants), 197 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 16.6), small intestine (RPKM 14.3) and 17 other tissues.
Summary
The protein encoded by this gene associates with membrane-bound phosphatidylinositols generated by phosphatidylinositol 3-kinase. The encoded protein then interacts with the actin Cytoskeleton to induce cell spreading. In conjunction with Complement Component 1, q subcomponent, B chain (C1QB), this gene shows an increase in expression in melanoma cells and may serve as an accurate biomarker for the disease. [provided by RefSeq, Dec 2015]
PLEK2 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_016445.3 | NP_057529.1 | pleckstrin-2 |
PLEK2 Protein Structure
PH: PH domain (6 - 99)
DEP: Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) (142 - 223)
PH: PH domain (248 - 353)
- 0
- 100
- 200
- 300
- 353 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
pleckstrin-2 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ecthyma |
|
|
| Melanoma |
|
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS10678 | PLEK2 Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS22732 | Plek2 Mouse Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
| HY-RS29246 | Plek2 Rat Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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