RNF6 - ring finger protein 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6049

About RNF6

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,132,115-26,223,085 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 18.5), brain (RPKM 11.7) and 25 other tissues.

Summary

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed. [provided by RefSeq, Jul 2008]

RNF6 Products (4)

mRNA Protein Name
NM_005977.4 NP_005968.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183043.3 NP_898864.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183044.3 NP_898865.1 E3 ubiquitin-protein ligase RNF6 isoform 1
NM_183045.1 NP_898866.1 E3 ubiquitin-protein ligase RNF6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear androgen receptor binding IPI
IPI: Inferred from physical interaction
19345326 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19345326 GOA
enables ubiquitin-protein transferase activity IMP
IMP: Inferred from mutant phenotype
19345326 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19345326 GOA
involved in protein K27-linked ubiquitination IDA
IDA: Inferred from direct assay
19345326 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
19345326 GOA
involved in regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19345326 GOA
involved in regulation of androgen receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19345326 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19345326 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19345326 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF6 Protein Structure

zf-RING_2

zf-RING_2: Ring finger domain (632 - 673)

  • 0
  • 200
  • 400
  • 600
  • 685 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase RNF6

  • RING-H2 protein RNF-6

RNF6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNF6 Q9Y252 AR Homo sapiens P10275
Confocal
19345326
Intra
RNF6 Q9Y252 AR Homo sapiens P10275
CH-IP
19345326
Intra
RNF6 Q9Y252 AR Homo sapiens P10275
Anti Bait CoIP
19345326
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Esophagus Squamous Cell Carcinoma

  • Esophageal Squamous Cell Carcinoma

  • Oesophagus Squamous Cell Carcinoma

  • Scc Of Esophagus

  • Scc Of Oesophagus

  • Squamous Cell Carcinoma Of The Esophagus

  • Escc

  • Esophageal Epidermoid Carcinoma

  • Squamous Cell Esophageal Cancer

  • Squamous Cell Carcinoma Of Esophagus
Squamous Cell Carcinoma

  • Epidermoid Carcinoma

  • Squamous Cell Cancer

  • Carcinoma, Squamous Cell

  • Squamous Cell Skin Cancer

  • Malignant Squamous Cell Tumor

  • Squamous Carcinoma

  • Squamous Cell Epithelioma

  • Carcinoma Squamous Cell

  • Neoplasms, Squamous Cell

  • Squamous Cell Carcinoma - Category

  • Malignant Squamous Cell Neoplasm

  • Squamous Cell Carcinoma Of Skin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12095 RNF6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RNF6 VGNC VGNC:34071
Felis catus RNF6 VGNC VGNC:64706
Canis familiaris RNF6 VGNC VGNC:45674
Macaca mulatta RNF6 VGNC VGNC:82225
Mus musculus RNF6 MGD MGI:1921382
Rattus norvegicus RNF6 RGD RGD:1306092
Others RNF6 NCBI