Synthesis and antitumor activity of novel quinazoline derivatives containing thiosemicarbazide moiety

  • Eur J Med Chem. 2012 Aug:54:925-30. doi: 10.1016/j.ejmech.2012.06.003.
Junbo He  1 ,  Xiaoguo Wang ,  Xiaoqin Zhao ,  Yongju Liang ,  Hongwu He ,  Liwu Fu
Affiliations
  • 1. Key Laboratory of Pesiticide & Chemistry Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan 430079, PR China.
PMID: 22749192 DOI: 10.1016/j.ejmech.2012.06.003
Abstract

Series of novel derivatives of quinazoline containing thiosemicarbazide moiety 5 and 9 have been synthesized and tested for their antitumor activities in vitro against a panel of five human Cancer cell lines. Bioassay results indicated that most of the prepared compounds exhibited cytotoxicity against various Cancer cells. From the structure-activity relationships it was found that unsubstituted quinazoline ring and benzene ring or halogen substituted benzene ring in quinazoline derivatives 5 and 9 would be the most favorable for their antitumor activity.