3126105-55-0
3126105-55-0
Chemical Structure
ITK-IN-7
- CAS No.: 3126105-55-0
- Formula:C27H35N7O2
- Molecular Weight:489.61
InChIKey: PLMMVXUXUHWPNP-QFIPXVFZSA-N
SMILES: O=C(C1=NNC2=C1CCC(C)(C)C2)NC3=CN([C@H](C4=CC=CC=C4)CCN(C)C)N=C3NC(C=C)=O
Biological Activity: ITK-IN-7 is a selective ITK inhibitor with an IC50 of 16 nM and a Ki of 0.48 nM. ITK-IN-7 reduces IL-2 secretion levels in T cells and in mouse models stimulated by anti-CD3 monoclonal antibodies. ITK-IN-7 can be used for basic and translational research related to ITK inhibition, such as research on leukemia[1].
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ITK-IN-7 | ITK-IN-7 is a selective ITK inhibitor with an IC50 of 16 nM and a Ki of 0.48 nM. ITK-IN-7 reduces IL-2 secretion levels in T cells and in mouse models stimulated by anti-CD3 monoclonal antibodies. ITK-IN-7 can be used for basic and translational research related to ITK inhibition, such as research on leukemia. | |||||||||||||||||||||
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References
Keywords
