Grip1 - glutamate receptor interacting protein 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84016

Summary

Enables signaling receptor binding activity. Involved in dendrite arborization; positive regulation of neuron projection arborization; and protein transport. Located in neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in Fraser syndrome 3. Orthologous to human GRIP1 (glutamate receptor interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Grip1 Products (1)

mRNA Protein Name
NM_032069.1 NP_114458.1 glutamate receptor-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
21847098 RGD
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
17084383 RGD
enables ionotropic glutamate receptor binding IDA
IDA: Inferred from direct assay
11007883 RGD
enables ionotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
10896157 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9647694 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21847098 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
16037816 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to brain-derived neurotrophic factor stimulus IDA
IDA: Inferred from direct assay
14597197 RGD
involved in cellular response to phorbol 13-acetate 12-myristate IDA
IDA: Inferred from direct assay
11007883 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
14597197 RGD
involved in dendrite arborization IMP
IMP: Inferred from mutant phenotype
15965473 RGD
involved in negative regulation of AMPA receptor activity IMP
IMP: Inferred from mutant phenotype
12597860 RGD
involved in nervous system development IMP
IMP: Inferred from mutant phenotype
11931740 RGD
involved in positive regulation of dendrite morphogenesis IMP
IMP: Inferred from mutant phenotype
15965473 RGD
involved in positive regulation of neuron projection arborization IGI
IGI: Inferred from genetic interaction
25424568 RGD
involved in positive regulation of neuron projection arborization IMP
IMP: Inferred from mutant phenotype
15965473 RGD
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
17207582 RGD
involved in regulation of kainate selective glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
12597860 RGD
involved in regulation of synaptic scaling IMP
IMP: Inferred from mutant phenotype
26109571 RGD
Cellular Component GO Annotation Evidence References Source
located in GABA-ergic synapse IDA
IDA: Inferred from direct assay
15226318 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15912503 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
17626212 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
17626212 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
11007883 RGD
located in dendritic spine neck IDA
IDA: Inferred from direct assay
11007883 RGD
part of exocyst IDA
IDA: Inferred from direct assay
26109571 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10436050 RGD
located in glutamatergic synapse IDA
IDA: Inferred from direct assay
15226318 RGD
located in microtubule IDA
IDA: Inferred from direct assay
15226318 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
1041498 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15226318 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
9069286 RGD
located in postsynapse IDA
IDA: Inferred from direct assay
18315564 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10436050 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
15226318 RGD
located in presynapse IDA
IDA: Inferred from direct assay
26109571 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
15912503 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
15226318 RGD
located in proximal dendrite IDA
IDA: Inferred from direct assay
11978826 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
20956289 RGD
located in spine synapse IDA
IDA: Inferred from direct assay
11007883 RGD
located in synaptic cleft IDA
IDA: Inferred from direct assay
26109571 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
15912503 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
15226318 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutamate receptor-interacting protein 1

  • AMPA receptor-interacting protein GRIP1

  • GRIP-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09090 NCOA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05809 GRIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19007 Grip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19721 Ncoa2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25496 Grip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26217 Ncoa2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grip1 NCBI NCBI:23426